The paper deals with the idea that a common river-Danube- can cover a lot of disparities connected to socio-economic, cultural, historical and religious approaches. As a result, the analysis in the paper is focused on economic disparities in all Danube countries, even that they are members or not of the EU27. The analysis is based on the latest official statistical data and is followed by a forecast for 2013-2014 in order to observe if the disparities will decrease or not. The main conclusion of the paper is that Danube can be a way and an instrument to solve regional disparities. The same Danube River can support a better socio-economic integration of the Danube countries, as well.