The article discusses the features of modern geo-demographic processes in the Ukrainian Danube and the effects on them of ethnic factor. Traditionally, multi-ethnic composition of the population is causes the most favorable in the Odessa region geo-demographic processes. After 1994 and in ranges of compact settlement of ethno-national groups starts watching depopulation. Modern geo-demographic processes define recovery reality sex and age structure of the population or in the region, there will be a further intensification of depopulation processes.