The state of geo-demographic situation in the Danube region, which is formed during this period is examined. Unfortunately, in recent time within the Danube Region geodemographic indicators have worsened (decreased natality, quickly began to grow on mortality rates), as a result is a population loss due to natural causes. Although the overall performance of geo-demographic process here is much better than in other administrative areas of the Odessa region, yet in the Danube region for the last years, they are characterized by negative values and the population here is also reduced mainly due to natural causes.